Wound healing is a complex sequence of events involving cellular and molecular processes such as cell migration, inflammation, angiogenesis, collagen synthesis, deposition and re-epithelialization.
The macrophages have crucial role in healing process.
As phagocytes, the macrophages help in digestion of bacteria and debridement. Macrophages also influence endothelial cell proliferation and angiogenesis, collagen synthesis and deposition, and re-epithelialization.
Macrophages result from a complex differentiation pathway of monocytes.
The monocytes egress the blood stream into tissues and differentiate into different kinds of macrophages, depending on the nature of the signals in the local microenvironment. Macrophages constitute a major widely dispersed cell population that regulates homoeostasis and responds to tissue injury by contributing essential functions during inflammation and repair.
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